Fig. 5

Average time courses of BOLD signals in various brain areas. The average BOLD signals are plotted in dark colors and the standard errors are shown in light blue. All ROIs are labeled with arrows in the insets. The dashed red lines indicate the boundary of |z-score| = 2.33 (P < .01). The SNI nerve transection induced a transient positive BOLD response followed by gradually enhanced BOLD signals in the bilateral ICs and S1HL area contralateral to the SNI hind limb, whereas the CC exhibited a robust positive response followed by sustained low level activity. In addition, the CPu exhibited a strong negative BOLD response after nerve transection. The contralateral auditory cortex (Aud) was selected as the control ROI to verify the BOLD signal stability. No evident BOLD signal changes were observed in the Aud after SNI. In these time courses, the first 140 scans (from − 280 to 0 s before nerve transection) show the BOLD signals under the resting baseline condition. SNI nerve transection was conducted upon initiation of the 141st scan (time = 0; n = 7)