Skip to main content
Fig. 7 | Molecular Brain

Fig. 7

From: Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury

Fig. 7

Unit responses during SNI surgery. SNI nerve transection induced a sustained increase in spike activity in the bilateral RAIC and contralateral S1HL are of the injured hind limb, whereas the CC exhibited no significant changes. The spike rates of each unit were converted to z-scores by using the following equation: (FRi – FRb)/SDb, where FRi is the firing rate in the ith bin of the recording period (5 s for each bin) and FRb and SDb represent the mean firing rate and standard deviation of firing rates before SNI nerve transection, respectively. The group z-scores were averaged from the mean z-scores of individuals. The spike activities under the resting baseline condition from − 300 to 0 s are shown. SNI nerve transection was performed at time = 0 and followed by 1200 s of post-SNI recording (gray area). The dashed red line shows the threshold of P < .05 (total unit number/number of rats in each group: 25/3 in the ipsilateral RAIC, 23/3 in the contralateral RAIC, 22/3 in the S1HL area, and 30/3 in the CC)

Back to article page