Fig. 1
From: Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
Modulation of NMDA receptors by cellular prion protein. a. NMDAR-mediated currents from hippocampal neuron cultures of Tga20 and Tg650 knock-in mice, versus wild-tpye C57. Neurons were held at − 60 mV throughout and currents were evoked by applciation of 500 μM NMDA, 1 μM glycine. b. Glycine dose response curve of the percentage of steady-state current (normalized to peak) in wild-type C57, Tga20 and Tg650 mice. c. Glycine dose response curve of the peak current in wild-type C57, Tga20 and Tg650 mice. d. Glycine dose response curve of the current area integration in wild-type C57, Tga20 and Tg650 mice. Unless stated otherwise, n = 5. Asterisks denote statistical significance for C57 vs Tg650 data, and number symbols indicate statistical significance between C57 and Tga20 (one way ANOVA)