Fig. 3
From: Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
Modulation of AMPA receptors by copper ions. a. sample traces of AMPA receptor currents in C57 and Tg650 neurons in either 10 μM copper, or 10 μM copper + 20 μM BCS (nominally zero free copper). b. Steady state AMPA current (normalized to peak) obtained from C57, Tga20 and Tg650 mouse hippocampal neurons in the presence of 10 μM copper, or 10 μM copper plus 20 μM BCS. c. Comparison of peak currents before and after BCS application as in panel a. d. Integrated current area under the conditions of panels a and b. Asterisks denote statistical significance (paired t-test)