Fig. 1

mGluR5-dependent increased CA1 neuronal excitability is mediated by enhancement of I_Na,P. a Left, schematic diagram illustrating the recording configuration showing somatic current-clamp recording (CC) with extracellular electrodes positioned to stimulate SC inputs. Right, representative traces demonstrated HFS-increased number of spikes in response to square current injections before HFS (black), after HFS (red), and after HFS in riluzole (blue, 10 μM). b Left, number of spikes evoked by somatic current injections was counted and plotted against time (n = 5). Right, pooled data of the mean number of spikes during somatic current injection obtained for first 1 min in each condition (n = 5, control vs HFS, *P < 0.05). c Top, inset shows superimposed view corresponding to the box shown in (a). Bottom, pooled data of the afterpotential following square currents injections in different conditions (n = 5). d Left, representative traces demonstrate the effects of MPEP (10 μM) on HFS-induced changes of number of spikes. Right, summary plots of the mean number of spikes evoked by somatic current injections as a function of time (n = 9)