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Fig. 2 | Molecular Brain

Fig. 2

From: proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

Fig. 2

Hippocampal proBDNF is modiffied by AGE in AD human samples. Representative immunofluorescence pictures stained with DAPI (a, e), anti-proBDNF (b, f), anti-CEL (c, g) at control and AD cases. i) Quantification of CEL and proBDNF co-localization in the AD is significantly increased respect to the controls. Positive cells are considered those with staining in the whole cell body. Bars represent the mean of 5 control and 5 AD samples as % colocalization of CEL and proBDNF respect to the total cell number (DAPI staining) ± SD . 300 total cells from each sample are counted. j) Representative image of Immunoprecipitation of proBDNF from CSF from controls and AD patients analyzed by Western-blot with antibodies against CEL. k) Bars represent the mean of 9 control and 9 AD samples as the percentage of the highest value in each WB, corrected for the corresponding densitometric values of the Coomassie-stained membrane.Scale bar =50 μm . *** p < 0,001, two tailed Student’s “t” test

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Molecular Brain

ISSN: 1756-6606