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Fig. 3 | Molecular Brain

Fig. 3

From: Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet

Fig. 3

Chemical shift imaging of hyperpolarized 13C MR spectroscopy. (a) Color maps overlaid on the 1H images represent [1-13C] pyruvate and [1-13C] lactate peak intensities, and[1-13C] lactate/[1-13C] pyruvate intensity ratios. The images were acquired for35s from 18 s after intravenous injection of 79 mM hyperpolarized 13C-pyruvate in the coronal plane with 3.5 mm slice thickness and 1 × 1 mm2 in-plain resolution. (b) [1-13C] lactate/[1-13C] pyruvate intensity ratios in the whole brain. (c) [1-13C] lactate/[1-13C] pyruvate intensity ratios in the Medial temporal lobe

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Molecular Brain

ISSN: 1756-6606