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Fig. 6 | Molecular Brain

Fig. 6

From: Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet

Fig. 6

Mice fed HFD showed cognitive impairment. (a) Escape latency is the spending time for the mice to find the submerged platform during training days. HFD-fed mice showed impaired spatial learning memory function compared to controls. The time spent in the respective quadrant searching the platform at the probe test for the control group (b) and HFD-fed group (b). Control mice spent significantly more time in the target quadrant. (d) Representative swim paths during probe trial. (e) The crossing number of the platform location. (f) Total distance moved during the probe test. (g) Preference for the object which is displaced to a novel location as the percent time. (h) Discrimination index = [(Tnovel– Tfamiliar)/(Tnovel+ Tfamiliar)]; Tnovel, time spent on exploring the novel object; Tfamiliar, time spent on exploring the familiar object. (i) Total exploration time. Error bars represent standard error of the mean. p-values were obtained from two-way ANOVA with Bonferroni’s post-hoc test (a, g), from one-way ANOVA followed by Newman-Keuls post-hoc test (b, c), and from the two-tailed Student’s t-test to compare two independent groups (d, e, h i). (n = 10 for both groups, * p < 0.05)

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