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Fig. 7 | Molecular Brain

Fig. 7

From: Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet

Fig. 7

Mice fed HFD for 3 months showed increased lactate conversion in hyperpolarized 13C MRS without cognitive decline. (a) Experimental schedule. (b) Body weight was measured every 4 weeks on each diet group. (c) Fasting serum glucose level. (d) Escape latency is the spending time for the mice to find the submerged platform during training days. Escape latency had no significant difference between ND and HFD group. (e) The time spent in the target quadrant searching the platform at the probe test for each group. ND and HFD group show no significance in exploration time in the target quadrant. (n = 10 for both groups, * p < 0.05) (f) The box plot shows the total hyperpolarized 13C signal from the brain obtained for 10 s after the injection and there was no difference. (g) The dynamic conversion ratio of hyperpolarized [1-13C] pyruvate/[1-13C]lactate calculated from the dynamic peak intensities (p < .0001). Shaded regions represent standard error of the mean value (n = 5 for both groups)

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