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Fig. 3 | Molecular Brain

Fig. 3

From: EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway

Fig. 3

EriB reduced proinflammatory cytokines production and shifted microglia subtype in PD mice model. a mRNA level of IFN-γ, TNF-α, IL-1β and IL-6 in SN area after MPTP and EriB injection on 6th day. b mRNA level of MHC-II, MCP-1, MIP-1α and IP-10 in SN area after MPTP and EriB injection on 8th day. iNOS (c), CD86 (d), Arg1 (e) and CD206 (f) mRNA level in SN area after MPTP and EriB injection on 6th day, 8th day and 12th day. g Western-blot detected the iNOS and Arg1 protein level in SN area after MPTP and EriB injection on 6th day and 12th day. h Western-blot analysis the IкBα, p65 and p-p65 level in SN area after MPTP and EriB injection on 6th day. *: vs control, #: vs MPTP group. *&#: P<0.05, **&##: P<0.01

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