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Fig. 5 | Molecular Brain

Fig. 5

From: EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway

Fig. 5

Effect of EriB on inhibiting microglia activation was mediated via the NF-κB signaling pathway. a protein level of IFN-γ, TNF-α, IL-1β and IL-6 after Mpp + and EriB stimuli. b iNOS, CD86, Arg1 and CD206 mRNA level after Mpp + and EriB stimuli. c Western-blot detected the iNOS and Arg1 protein level after Mpp + and EriB stimuli. d Western-blot analysis the NF-κB signaling pathway of cultured microglia after Mpp + and EriB stimuli. e immunocytochemical staining for p-p65 of cultured microglia after Mpp + and EriB stimuli, and statistical analysis of the percentage of p-p65 and DAPI double staining in cultured microglia after Mpp + and EriB stimuli. Scale bar: 25 μm. *: vs control, #: vs Mpp + group. *&#: P<0.05, **&##: P<0.01

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