Fig. 1
From: What does LTP tell us about the roles of CaMKII and PKMζ in memory?
PKMζ and CaMKII inhibition differ in their effects on LTP and basal synaptic transmission. A) Above, schematic representation showing PKMζ inhibition reverses late-LTP when inhibitors are applied after late-LTP is established. After the inhibitor is eliminated, the potentiation does not return, indicating PKMζ’s role in maintaining late-LTP. Below, in a separate synaptic pathway, PKMζ inhibition has no effect on basal, untetanized synaptic transmission. PKMζ inhibition has no effect on early-LTP maintenance (not shown). B) The effects of CaMKII inhibition depend on the mechanism of inhibition. B1) Inhibition of CaMKII activity blocks LTP induction (above), but has no effect on LTP maintenance (middle) or basal synaptic transmission (below). B2) Disrupting the interaction between CaMKII and NMDAR decreases both early-LTP (above) and basal synaptic transmission (below) with no specificity for potentiated vs. unpotentiated synapses. Elimination of the blockers of CaMKII-NMDAR interaction shows incomplete reversal, indicating an effect on the maintenance of AMPAR-mediated synaptic transmission