Fig. 1

Schedule of experimental design and rapamycin treatment. (a) Body maturation and motor function were assessed from P7 to P25. The social interaction test was conducted in both adolescence (5–6 weeks of age) and adulthood (10–11 weeks of age). The mice were scarified to sample whole brains. R, righting reflex test; Eye, eye-opening test; HW, hanging wire test; BW, body weight; Ra, rapamycin; Ve, vehicle; Social, social interaction test. (b) The mice were reared with their littermates. A mouse that was injected with vehicle in adolescence was injected with rapamycin in adulthood. Conversely, a mouse that was injected with rapamycin in adolescence was injected with vehicle in adulthood