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Fig. 2 | Molecular Brain

Fig. 2

From: Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

Fig. 2

Identification of subtypes of GABAergic neurons derived from human iPSCs. (a) Quantitative gene-expression analysis of the subtypes of GABAergic neurons revealed that the main population of GABAergic neurons was SST-expressing neurons in control-and PARK2 (PA and PB)-derived GABAergic neurons (day 30, n = 3). Abbreviations; SST, somatostatin; PV, parvalbumin; NOS1, nitric oxide synthase 1; VIP, vasoactive intestinal peptide; CCK, cholecystokinin; CR, calretinin; CB, calbindin; RELN, reelin; NPY, neuropeptide Y; HTR3A, 5-hydroxytryptamine receptor 3A. (b) Immunocytochemical analysis for the major subtypes of GABAergic interneuron markers, SST and PV, and the GABAergic neuron marker (GABA) of PARK2 (PA and PB) and control iPSC-derived GABAergic neurons. Scale bar, 50 μm

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Molecular Brain

ISSN: 1756-6606