Baicalin regulates the dopamine system to control the core symptoms of ADHD

Table 3 Moving distance in the open field test (mean ± SEM, m, n = 10)

Group	Week 0	Week 1	Week 2	Week 3	Week 4
WKY + saline	21.66 ± 2.67	19.47 ± 2.24	15.16 ± 2.27	12.55 ± 1.63	9.78 ± 2.75
SHR + saline	43.84 ± 2.39^##	42.18 ± 2.03^##	40.04 ± 2.35^##	39.60 ± 2.22^##	40.51 ± 1.79^##
SHR + MPH(1.5 mg/kg)	46.34 ± 3.13	26.66 ± 2.67^**	21.14 ± 2.30^**	17.69 ± 2.46^**	12.23 ± 2.22^**
SHR + baicalin(50 mg/kg)	45.06 ± 1.48	41.57 ± 1.75	38.89 ± 2.71	29.12 ± 2.57^*	23.41 ± 2.87^**
SHR + baicalin(100 mg/kg)	44.89 ± 3.42	41.01 ± 2.82	31.64 ± 2.58^*	26.77 ± 1.90^**	21.19 ± 3.48^**
SHR + baicalin(150 mg/kg)	46.48 ± 2.80	33.24 ± 1.75^*	24.54 ± 1.63^**	17.52 ± 1.76^**	14.26 ± 2.83^**

Note: Comparison of the moving distance in the open field test in all groups; values are expressed as the mean ± S.E.M. ^#p < 0.05 and ^##p < 0.01 versus WKY + saline group; ^*p < 0.05 and ^**p < 0.01 versus SHR + saline group

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