Baicalin regulates the dopamine system to control the core symptoms of ADHD

Table 4 Moving speed in the open field test (mean ± SEM, cm/s, n = 10)

Group	Week 0	Week 1	Week 2	Week 3	Week 4
WKY + saline	7.09 ± 0.68	6.71 ± 1.25	6.00 ± 1.16	4.66 ± 1.03	4.01 ± 1.28
SHR + saline	20.46 ± 1.45^##	17.37 ± 0.91^##	18.51 ± 1.03^##	17.65 ± 1.34^##	18.23 ± 1.54^##
SHR + MPH(1.5 mg/kg)	18.73 ± 1.07	11.56 ± 1.10^**	8.81 ± 1.29^**	6.80 ± 1.45^**	4.10 ± 1.42^**
SHR + baicalin(50 mg/kg)	18.36 ± 1.00	16.75 ± 1.67	15.93 ± 1.50	11.08 ± 0.47^*	9.98 ± 1.29^**
SHR + baicalin(100 mg/kg)	19.75 ± 1.61	16.54 ± 1.06	10.16 ± 0.89^**	8.76 ± 1.17^**	5.95 ± 0.72^**
SHR + baicalin(150 mg/kg)	18.15 ± 1.14	13.41 ± 0.98^*	9.12 ± 1.02^**	6.84 ± 1.92^**	4.64 ± 1.14^**

Note: Comparison of the moving speed in open field test in all groups; values are expressed as the mean ± S.E.M. ^#p < 0.05 and ^##p < 0.01 versus WKY + saline group; ^*p < 0.05 and ^**p < 0.01 versus SHR + saline group

ISSN: 1756-6606