Baicalin regulates the dopamine system to control the core symptoms of ADHD

Table 5 Escape latency in the Morries Water Maze test (mean ± SEM, s, n = 10)

Group	Day1	Day2	Day3	Day4	Day5
WKY + saline	56.14 ± 3.51	48.71 ± 4.30	45.01 ± 3.69	39.94 ± 2.62	40.78 ± 1.52
SHR + saline	68.22 ± 3.13^##	61.96 ± 3.89^##	54.51 ± 4.89^##	54.76 ± 4.63^##	50.82 ± 5.49^#
SHR + MPH(1.5 mg/kg)	53.96 ± 1.92^**	36.18 ± 2.37^**	32.18 ± 2.24^**	25.28 ± 2.18^**	21.82 ± 2.33^**
SHR + baicalin(50 mg/kg)	50.83 ± 4.40^**	46.65 ± 2.95^**	40.88 ± 2.67^**	41.35 ± 1.73^**	38.72 ± 2.03^**
SHR + baicalin(100 mg/kg)	49.82 ± 2.98^**	37.17 ± 2.38^**	33.34 ± 2.24^**	32.87 ± 1.58^**	32.58 ± 1.78^**
SHR + baicalin(150 mg/kg)	45.37 ± 3.41^**	40.49 ± 2.36^**	33.02 ± 3.19^**	27.81 ± 2.72^**	24.87 ± 1.85^**

Note: Comparison of the escape latency in Morries water maze in all groups; values are expressed as the mean ± S.E.M. ^#p < 0.05 and ^##p < 0.01 versus WKY + saline group; ^*p < 0.05 and ^**p < 0.01 versus SHR + saline group

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