Fig. 1

Enrichment of heritability within entorhinal cortex H3H27ac peaks. a Bar plot of total heritability estimates calculated across genetic variants located within any functional element. b Bar plot of cortical H3K27ac enrichment statistics. Enrichment was calculated as the proportion of heritability divided by the proportion of variants within autosomal H3K27ac peaks in the entorhinal cortex, relative to values for the set of more broadly defined functional elements derived from cross-tissue datasets. Error bars represent 95% confidence intervals; dashed horizontal lines indicate null values