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Table 1 Enrichment of heritability within entorhinal cortex H3K27ac peaks

From: Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains

Trait (date GWAS published)

Total observed heritability

Partitioned heritability for EC H3K27ac peaks

Enrichment

Estimate

SE

95% CI Lower

95% CI Upper

Estimate

SE

95% CI Lower

95% CI Upper

Estimate

SE

95% CI Lower

95% CI Upper

A

ADHD (2017)

0.073

0.010

0.054

0.092

0.039

0.009

0.021

0.057

1.534

0.026

1.483

1.585

ALS (2016)

0.054

0.011

0.032

0.075

0.041

0.013

0.015

0.067

2.199

0.038

2.125

2.274

Alzheimer’s disease (2013)

0.079

0.011

0.058

0.099

0.030

0.009

0.013

0.048

1.097

0.026

1.047

1.148

Autism (2017)

0.072

0.012

0.049

0.095

0.053

0.010

0.034

0.072

2.108

0.027

2.055

2.162

Bipolar disorder (2012)

0.071

0.007

0.057

0.085

0.046

0.008

0.031

0.060

1.836

0.022

1.793

1.879

MDD (2012)

0.067

0.020

0.028

0.107

0.048

0.021

0.006

0.090

2.036

0.061

1.916

2.155

Schizophrenia (2012)

0.120

0.011

0.098

0.142

0.064

0.012

0.041

0.088

1.533

0.034

1.466

1.600

Schizophrenia (2014)

0.222

0.014

0.196

0.249

0.146

0.013

0.121

0.170

1.879

0.036

1.809

1.950

Schizophrenia (2018)

0.237

0.012

0.214

0.260

0.145

0.012

0.122

0.168

1.758

0.034

1.692

1.824

B

Birth length (2015)

0.151

0.018

0.116

0.186

0.050

0.017

0.016

0.084

0.947

0.050

0.850

1.044

BMI (2015)

0.072

0.004

0.064

0.079

0.034

0.004

0.027

0.042

1.378

0.011

1.356

1.401

BMI (2018)

0.124

0.006

0.112

0.136

0.050

0.005

0.040

0.060

1.162

0.015

1.132

1.192

Cigarettes per day (2010)

0.033

0.011

0.012

0.054

0.010

0.009

−0.008

0.028

0.876

0.026

0.825

0.928

Coronary artery disease (2014)

0.064

0.006

0.052

0.075

0.019

0.006

0.008

0.030

0.855

0.016

0.823

0.887

Crohn’s disease (2015)

0.475

0.039

0.399

0.551

0.129

0.038

0.055

0.202

0.776

0.108

0.564

0.987

Ever smoked (2010)

0.029

0.005

0.020

0.038

0.021

0.006

0.010

0.032

2.067

0.016

2.035

2.099

HDL (2013)

0.180

0.018

0.146

0.214

0.096

0.015

0.066

0.126

1.533

0.044

1.447

1.619

Height (2014)

0.299

0.013

0.273

0.325

0.079

0.010

0.058

0.099

0.754

0.030

0.696

0.813

Height (2018)

0.452

0.020

0.412

0.492

0.110

0.017

0.077

0.144

0.701

0.049

0.604

0.797

Inflammatory bowel disease (2015)

0.322

0.027

0.269

0.374

0.063

0.021

0.023

0.103

0.564

0.059

0.449

0.679

LDL (2013)

0.167

0.020

0.128

0.206

0.057

0.016

0.026

0.087

0.971

0.044

0.884

1.058

Total cholestrol (2013)

0.197

0.021

0.155

0.239

0.072

0.018

0.036

0.108

1.053

0.053

0.950

1.157

Triglycerides (2013)

0.163

0.019

0.126

0.200

0.076

0.015

0.045

0.106

1.329

0.044

1.242

1.416

Type 2 diabetes (2012)

0.066

0.008

0.051

0.081

0.009

0.007

−0.006

0.023

0.372

0.021

0.330

0.413

Ulcerative colitis (2015)

0.267

0.029

0.209

0.324

0.038

0.020

−0.001

0.076

0.406

0.056

0.296

0.516

  1. Heritability and enrichment statistics from partitioned heritability analysis performed using the LD score regression software for A) brain traits and B) non-brain traits. EC = entorhinal cortex