From: Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
Trait (date GWAS published) | Total observed heritability | Partitioned heritability for EC H3K27ac peaks | Enrichment | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Estimate | SE | 95% CI Lower | 95% CI Upper | Estimate | SE | 95% CI Lower | 95% CI Upper | Estimate | SE | 95% CI Lower | 95% CI Upper | |
A | ||||||||||||
ADHD (2017) | 0.073 | 0.010 | 0.054 | 0.092 | 0.039 | 0.009 | 0.021 | 0.057 | 1.534 | 0.026 | 1.483 | 1.585 |
ALS (2016) | 0.054 | 0.011 | 0.032 | 0.075 | 0.041 | 0.013 | 0.015 | 0.067 | 2.199 | 0.038 | 2.125 | 2.274 |
Alzheimer’s disease (2013) | 0.079 | 0.011 | 0.058 | 0.099 | 0.030 | 0.009 | 0.013 | 0.048 | 1.097 | 0.026 | 1.047 | 1.148 |
Autism (2017) | 0.072 | 0.012 | 0.049 | 0.095 | 0.053 | 0.010 | 0.034 | 0.072 | 2.108 | 0.027 | 2.055 | 2.162 |
Bipolar disorder (2012) | 0.071 | 0.007 | 0.057 | 0.085 | 0.046 | 0.008 | 0.031 | 0.060 | 1.836 | 0.022 | 1.793 | 1.879 |
MDD (2012) | 0.067 | 0.020 | 0.028 | 0.107 | 0.048 | 0.021 | 0.006 | 0.090 | 2.036 | 0.061 | 1.916 | 2.155 |
Schizophrenia (2012) | 0.120 | 0.011 | 0.098 | 0.142 | 0.064 | 0.012 | 0.041 | 0.088 | 1.533 | 0.034 | 1.466 | 1.600 |
Schizophrenia (2014) | 0.222 | 0.014 | 0.196 | 0.249 | 0.146 | 0.013 | 0.121 | 0.170 | 1.879 | 0.036 | 1.809 | 1.950 |
Schizophrenia (2018) | 0.237 | 0.012 | 0.214 | 0.260 | 0.145 | 0.012 | 0.122 | 0.168 | 1.758 | 0.034 | 1.692 | 1.824 |
B | ||||||||||||
Birth length (2015) | 0.151 | 0.018 | 0.116 | 0.186 | 0.050 | 0.017 | 0.016 | 0.084 | 0.947 | 0.050 | 0.850 | 1.044 |
BMI (2015) | 0.072 | 0.004 | 0.064 | 0.079 | 0.034 | 0.004 | 0.027 | 0.042 | 1.378 | 0.011 | 1.356 | 1.401 |
BMI (2018) | 0.124 | 0.006 | 0.112 | 0.136 | 0.050 | 0.005 | 0.040 | 0.060 | 1.162 | 0.015 | 1.132 | 1.192 |
Cigarettes per day (2010) | 0.033 | 0.011 | 0.012 | 0.054 | 0.010 | 0.009 | −0.008 | 0.028 | 0.876 | 0.026 | 0.825 | 0.928 |
Coronary artery disease (2014) | 0.064 | 0.006 | 0.052 | 0.075 | 0.019 | 0.006 | 0.008 | 0.030 | 0.855 | 0.016 | 0.823 | 0.887 |
Crohn’s disease (2015) | 0.475 | 0.039 | 0.399 | 0.551 | 0.129 | 0.038 | 0.055 | 0.202 | 0.776 | 0.108 | 0.564 | 0.987 |
Ever smoked (2010) | 0.029 | 0.005 | 0.020 | 0.038 | 0.021 | 0.006 | 0.010 | 0.032 | 2.067 | 0.016 | 2.035 | 2.099 |
HDL (2013) | 0.180 | 0.018 | 0.146 | 0.214 | 0.096 | 0.015 | 0.066 | 0.126 | 1.533 | 0.044 | 1.447 | 1.619 |
Height (2014) | 0.299 | 0.013 | 0.273 | 0.325 | 0.079 | 0.010 | 0.058 | 0.099 | 0.754 | 0.030 | 0.696 | 0.813 |
Height (2018) | 0.452 | 0.020 | 0.412 | 0.492 | 0.110 | 0.017 | 0.077 | 0.144 | 0.701 | 0.049 | 0.604 | 0.797 |
Inflammatory bowel disease (2015) | 0.322 | 0.027 | 0.269 | 0.374 | 0.063 | 0.021 | 0.023 | 0.103 | 0.564 | 0.059 | 0.449 | 0.679 |
LDL (2013) | 0.167 | 0.020 | 0.128 | 0.206 | 0.057 | 0.016 | 0.026 | 0.087 | 0.971 | 0.044 | 0.884 | 1.058 |
Total cholestrol (2013) | 0.197 | 0.021 | 0.155 | 0.239 | 0.072 | 0.018 | 0.036 | 0.108 | 1.053 | 0.053 | 0.950 | 1.157 |
Triglycerides (2013) | 0.163 | 0.019 | 0.126 | 0.200 | 0.076 | 0.015 | 0.045 | 0.106 | 1.329 | 0.044 | 1.242 | 1.416 |
Type 2 diabetes (2012) | 0.066 | 0.008 | 0.051 | 0.081 | 0.009 | 0.007 | −0.006 | 0.023 | 0.372 | 0.021 | 0.330 | 0.413 |
Ulcerative colitis (2015) | 0.267 | 0.029 | 0.209 | 0.324 | 0.038 | 0.020 | −0.001 | 0.076 | 0.406 | 0.056 | 0.296 | 0.516 |