Fig. 4

Spinophilin deletion affects cocaine induction of Fos family IEGs. a Representative images for immunostaining of c-Fos in the striatum of wild-type and spinophilin-KO mice. Quantification of cocaine-induced expression of b) c-Fos and c) ∆Fosb mRNA levels in wild-type and spinophilin-KO mice. Data expressed as mean ± SEM. Two-way ANOVA followed by Tukey post-hoc. *p < 0.05 for the indicated comparisons, ^###p < 0.001 compared to all other groups and ^&&&p < 0.001 compared to saline-WT and saline-KO