Fig. 4
From: Sacs R272C missense homozygous mice develop an ataxia phenotype
Reduced Purkinje cell firing frequency in mice with R272C mutant sacsin. (a) Schematic representation of Purkinje cell loose-cell attached recording configuration (left) and sample traces for WT (top right, black) and SacsR272C mice (bottom right, grey) Purkinje cell action potential recordings. (b) Purkinje cell firing rate is significantly reduced in SacsR272C mice, while (c) the precision of firing, as reflected by CV, is unaffected. n.s. = P > 0.05; ** = P < 0.01