Fig. 9
From: Sacs R272C missense homozygous mice develop an ataxia phenotype
Mutant sacsin expression in SacsR272C mice. (a-f) Immunohistochemistry using antibody against sacsin on sagittal brain sections from 80 day-old SacsWT and SacsR272C mice demonstrate a reduced labeling in cell bodies (b), dendrites (b) and axons (d) of cerebellar Purkinje cells as well as in commissural fibers of the corpus callosum (f) of SacsR272C mice. Yellow boxes demonstrate fixed-sized regions of interest used for immunohistochemistry quantifications. (g) Means grey values of immunohistochemical sacsin labeling. Data represent means ± SEM, three mice per group. **P < 0.01, *P < 0.05 (One-tailed unpaired t test SacsR272C versus controls). Scale bar in F = 50 μm