Fig. 3

Anxiety-like behavior assessed by Open field test. Mice were placed in a cubic square under dim light and allowed to move freely for 10 min. Mice movement related to anxiety was assessed based on the time in center zone (a and d), entry number to center zone (b and e), total travel distance (c and f), and maximum speed (g). Panels a, b, and c show the results at 2 weeks PS, panels d-g show those at 4 weeks PS. Unpaired two-tailed t-test was performed. Data are represented as mean ± S.E.M. (n = 24/group at 2 weeks PS, n = 34/group at 4 weeks PS)