Fig. 5

Anxiety-like behavior assessment by light/dark box test. Mice at 4 weeks PS were freely moved in an arena divided by light and dark areas connected with a small door for 10 min. Animal movement in terms of transition frequency (a), retention time in lit area (b), and travel distance in lit are (c) were analyzed. Unpaired two-tailed t-test was performed. Data are represented as mean ± S.E.M. (n = 16/group)