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Table 1 Regulation of PTSD-associated genes

From: Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model

Gene symbol

Gene name

region

time

Regulation

Regulation in PTSD

Reference

Adcy8

adenylate cyclase 8

AMY

5

Up

 

[38]

Cacna1c

calcium voltage-gated channel subunit alpha1C

ACC

2

Dw

 

[72]

Crhr1

Corticotropin releasing hormone receptor 1

ACC

2

Up

 

[73]

Crhr2

Corticotropin releasing hormone receptor 2

ACC

2

Dw

 

[74]

Fkbp5

FK506 binding protein 5

ACC

2

Dw

Up (orbito-frontal cortex) or Dw (subgenual PFC)

[22, 75, 76]

Klhl1

Kelch like family member 1

AMY

2

Dw

 

[36]

Oxtr

Oxytocin receptor

AMY

2

Up

 

[77]

Rora

RAR related orphan receptor A

ACC

2

Up

 

[78]

Sgk1

serum/glucocorticoid regulated kinase 1

AMY

2

Dw

Dw (PFC)

[49, 79]

Shank1

SH3 and Multiple Ankyrin repeat doamin1

ACC

2

Dw

Up (subgenual PFC)

[75]

Stat5b

signal transducer and activator of transcription 5B

AMY

5

Dw

Dw (blood)

[50]

Tbc1d2

TBC1 Domain Family Member 2

AMY

2

Dw

 

[35]

Tbc1d2

TBC1 Domain Family Member 3

ACC

2

Up

 

[35]