Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 1 | Molecular Brain

Fig. 1

From: Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation

Fig. 1

Distinct depotentiation of LTP induced by compressed versus spaced theta burst stimulation (TBS). a Schematic for extracellular recordings at Schaffer collateral-commissural CA1 synapses from adult rat hippocampus. The induction protocols for compressed (c) and spaced (s) TBS are summarized below. b The effects of LFS (2 Hz for 10 min) indicated by the hatched grey bar on naïve (i.e., unconditioned) synapses (n = 8). c Representative traces for baseline, LTP and depotentiation from experiments f and g (timing indicated by numbers). d-m The effects of LFS on cTBS- and sTBS-induced LTP after 5 min (d and e; n = 11 and 6), 30 min (f and g; n = 11 and 10), 60 min (h and i; n = 11 and 10), 120 min (j and k; n = 6 and 8) and 180 min (l and m; n = 10 and 7) after the last TBS. n Summary plot for the levels of depotentiation for cTBS and sTBS. The level of depotentiation is expresssed as the % reversal (from the potentiated response to the initial baseline) measured 30 min after the end of LFS, and plotted according to the time between TBS3 and LFS (TBS3 ➔ LFS). Regressions are statistically different (*p < 0.05). o-p Potentiation of synaptic responses following cTBS (o) or sTBS (p) for pathways receiving LFS (red) and their controls (black). The plots reveal the time course of development of LTP

Back to article page