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Fig. 1 | Molecular Brain

Fig. 1

From: Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation

Fig. 1

Distinct depotentiation of LTP induced by compressed versus spaced theta burst stimulation (TBS). a Schematic for extracellular recordings at Schaffer collateral-commissural CA1 synapses from adult rat hippocampus. The induction protocols for compressed (c) and spaced (s) TBS are summarized below. b The effects of LFS (2 Hz for 10 min) indicated by the hatched grey bar on naïve (i.e., unconditioned) synapses (n = 8). c Representative traces for baseline, LTP and depotentiation from experiments f and g (timing indicated by numbers). d-m The effects of LFS on cTBS- and sTBS-induced LTP after 5 min (d and e; n = 11 and 6), 30 min (f and g; n = 11 and 10), 60 min (h and i; n = 11 and 10), 120 min (j and k; n = 6 and 8) and 180 min (l and m; n = 10 and 7) after the last TBS. n Summary plot for the levels of depotentiation for cTBS and sTBS. The level of depotentiation is expresssed as the % reversal (from the potentiated response to the initial baseline) measured 30 min after the end of LFS, and plotted according to the time between TBS3 and LFS (TBS3 ➔ LFS). Regressions are statistically different (*p < 0.05). o-p Potentiation of synaptic responses following cTBS (o) or sTBS (p) for pathways receiving LFS (red) and their controls (black). The plots reveal the time course of development of LTP

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