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Fig. 1 | Molecular Brain

Fig. 1

From: Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice

Fig. 1

Prenatal exposure to fluoxetine induces deficits in executive functions in male offspring. (a) Schematic diagram of the experimental design. From embryonic day 4 (ED4) to ED19, pregnant females received daily injections of either fluoxetine (FLX, 0.6 mg/kg/day) or saline (SAL). Male offspring were subjected to behavioral testing at 8–12 weeks of age. (b) Bar plot of spontaneous alternation rate on the Y-maze. (c) Bar plot of the total number of entries into all arms of the Y-maze. (d) Representative heat map images of results of the three-chamber social interaction test with a novel mouse and object. The occupancy rate was normalized to the region with peak occupancy in the arena. (e) Bar plot of the time spent sniffing the novel mouse and object in the three-chamber social interaction task. (f) Bar plot of the social preference index (time spent sniffing mouse/total time spent sniffing the mouse and the object). The dotted line indicates an equal preference (50%) (g) Representative heat map images of the results of the three-chamber social interaction tests with a familiar mouse and novel mouse. (h) Bar plot of the times spent sniffing the familiar mouse and novel mouse in the three-chamber social interaction task. (i) Bar plot of the social novelty preference index (time spent sniffing the novel mouse/total time spent sniffing both mice). Data are presented as means ± SEM. (e) and (h) Two-way repeated measures ANOVA. (b), (c), (f) and (i) Unpaired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001

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