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Fig. 3 | Molecular Brain

Fig. 3

From: Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice

Fig. 3

Increased excitability and serotonergic modulation of FS interneurons in PrL of FLX-treated mice. (a) Schematic diagram of the mouse PFC as outlined by the red dashed lines. The black box indicates a high magnification view of the neurons that were patched. We performed whole-cell patch-clamp recordings of putative fast-spiking (FS) interneurons in L5 of the PrL. (b) Representative image of a biocytin-filled FS interneuron in L5. Inset – co-staining for biocytin and parvalbumin, a marker of FS interneurons. (c) Characteristic responses of FS interneurons from SAL-treated mice to current injections (− 450 pA, 200 pA, and 450 pA) showing low adaptation to repeated firing. (d) Representative traces of FS interneurons from SAL-treated mice showing responses to current injections (200 pA) at baseline (CTRL), during the bath application of 5-HT (5-HT), and the bath application of the 5-HT2AR antagonist MDL. (e) Bar plot summarizing the effects of the 5-HT and MDL treatment on FS interneurons in SAL-treated mice (f) Representative traces of FS interneurons from FLX-treated mice show the responses to current injections (200 pA) under CTRL, 5-HT and MDL conditions. (g) Bar plot summarizing the effects of the 5-HT and MDL treatments on FS interneurons in FLX-treated mice. Data are presented as means ± SEM. All data were analyzed using the Wilcoxon signed ranks test. **p < 0.01

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