Fig. 1

Overexpression of CaMKII* in hippocampal CA1 region impairs context discrimination but not contextual fear conditioning. a schematic showing the experimental protocol (b) Mean percentage of time spent in freezing after 1 day of conditioning in shock context (n = 12 for control group, and n = 13 for overexpression group). c Mean percentage of time spent in freezing after 1 day of contextual conditioning in neutral context (n = 12 for control group, and n = 13 for overexpression group). d Mean percentage of discriminative ratio, which is calculated using freezing level in the shock context divided by (shock context freezing + neutral context freezing) (n = 12 for control group, and n = 13 for overexpression group). All graphs show mean ± SEM. Student’s t-test. N.S., not significant; *P < 0.05; **P < 0.01 versus control group. e Schematic showing the effect of CaMKII* overexpression in specific spine maturation during memory formation in the control and overexpression groups