Fig. 2
From: Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels
Gluconate inhibits Cl− current in cultured neurons. a, b Typical Cl− currents recorded before (red), during 10 mM NaGluc application (green), and wash out NaGluc (black). I-V curves showing a significant inhibition of NaGluc on the Cl− currents (n = 7 from 3 batches of cultures, paired Student’s t-test). c-f NPPB and DIDS (100 μM), two classical Cl− channel blockers, inhibited the Cl− currents in cultured neurons. g, h Both NPPB (g) and DIDS (h) inhibited the epileptiform activity induced by CTZ. Data are presented as mean ± s.e.m. ** P < 0.01, *** P < 0.001