Fig. 1
From: Absence of BBSome function leads to astrocyte reactivity in the brain
Congenital absence of BBSome function is associated with increased immunoreactivity in the brains of BBS mice as determined by GFAP, a pan reactive astrocyte marker. a Representative confocal 10X Tile images showing increased GFAP and VIMENTIN immunoreactivity in brains of BBS mice. Images were scanned using the same parameters for corresponding wildtype littermates (WT) and BBS null mice. b-e Best matched confocal images (63X magnification) of representative sub-brain regions from different strains of BBS mice showing increased GFAP immunoreactivity, a marker for reactive astrocytes, when compared to their WT littermates. Notably, increased GFAP immunoreactivity is observed in the hippocampus (b), corpus callosum(c), striatum(d), hypothalamus (e), and sub-ventricular zone (f) brain regions in BBS null mice when compared to their wild type littermates