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Table 1 GOs enriched for genes differentially expressed between heterozygous mutant and wild type sibling fish brains

From: Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production

Gene Ontology Term Ontology Total Genes DE Genes p-value FDR p-value
ATP biosynthetic process BP 29 7 3.48987E-08 0.00041
ribonucleoside triphosphate biosynthetic process BP 49 8 9.41317E-08 0.00045
nucleoside triphosphate biosynthetic process BP 54 8 2.06555E-07 0.00060
purine nucleoside triphosphate biosynthetic process BP 41 7 4.46237E-07 0.00060
purine ribonucleoside triphosphate biosynthetic process BP 41 7 4.46237E-07 0.00060
hydrogen transport BP 60 8 4.783E-07 0.00060
proton transport BP 60 8 4.783E-07 0.00060
energy coupled proton transport, down electrochemical gradient BP 27 6 5.89038E-07 0.00060
ATP synthesis coupled proton transport BP 27 6 5.89038E-07 0.00060
transport BP 2072 48 2.11748E-06 0.00165
purine nucleoside monophosphate biosynthetic process BP 54 7 3.09019E-06 0.00172
purine ribonucleoside monophosphate biosynthetic process BP 54 7 3.09019E-06 0.00172
hydrogen ion transmembrane transport BP 54 7 3.09019E-06 0.00172
ribonucleoside triphosphate metabolic process BP 133 10 3.8448E-06 0.00178
establishment of localization BP 2123 48 4.20295E-06 0.00182
ATP metabolic process BP 109 9 5.50772E-06 0.00230
nucleoside triphosphate metabolic process BP 140 10 6.08925E-06 0.00245
cation transport BP 452 18 6.61154E-06 0.00258
monovalent inorganic cation transport BP 219 12 1.10729E-05 0.00392
ribonucleoside monophosphate biosynthetic process BP 65 7 1.08944E-05 0.00392
nucleoside monophosphate biosynthetic process BP 68 7 1.47269E-05 0.00492
purine ribonucleoside triphosphate metabolic process BP 125 9 1.68142E-05 0.00546
purine nucleoside triphosphate metabolic process BP 126 9 1.79263E-05 0.00552
transmembrane transport BP 654 21 2.93288E-05 0.00797
purine nucleoside monophosphate metabolic process BP 136 9 3.2951E-05 0.00837
purine ribonucleoside monophosphate metabolic process BP 136 9 3.2951E-05 0.00837
energy coupled proton transmembrane transport, against electrochemical gradient BP 35 5 5.20342E-05 0.01106
ATP hydrolysis coupled proton transport BP 35 5 5.20342E-05 0.01106
ATP hydrolysis coupled transmembrane transport BP 35 5 5.20342E-05 0.01106
ATP hydrolysis coupled ion transmembrane transport BP 35 5 5.20342E-05 0.01106
ATP hydrolysis coupled cation transmembrane transport BP 35 5 5.20342E-05 0.01106
ion transport BP 737 22 5.61478E-05 0.01152
localization BP 2621 52 6.0913E-05 0.01207
ribonucleoside monophosphate metabolic process BP 147 9 6.06496E-05 0.01207
nucleoside monophosphate metabolic process BP 150 9 7.09445E-05 0.01360
single-organism localization BP 819 23 9.51294E-05 0.01738
single-organism transport BP 776 22 0.000119082 0.02109
ribonucleotide biosynthetic process BP 129 8 0.000143028 0.02423
ribose phosphate biosynthetic process BP 129 8 0.000143028 0.02423
vacuolar acidification BP 11 3 0.000246582 0.04101
ribonucleotide metabolic process BP 220 10 0.000281352 0.04506
proton-transporting two-sector ATPase complex, proton-transporting domain CC 25 6 3.59375E-07 0.00060
proton-transporting two-sector ATPase complex CC 45 7 8.65692E-07 0.00078
mitochondrial membrane CC 285 15 1.42199E-06 0.00119
mitochondrial envelope CC 303 15 3.0322E-06 0.00172
membrane part CC 4868 85 1.1722E-05 0.00403
organelle membrane CC 789 24 1.84982E-05 0.00555
mitochondrial inner membrane CC 195 11 1.97958E-05 0.00579
integral component of membrane CC 4419 78 2.52479E-05 0.00720
intrinsic component of membrane CC 4453 78 3.37749E-05 0.00840
organelle envelope CC 420 16 3.76291E-05 0.00917
envelope CC 422 16 3.98337E-05 0.00950
organelle inner membrane CC 215 11 4.86028E-05 0.01106
Cul2-RING ubiquitin ligase complex CC 7 3 5.4156E-05 0.01131
proton-transporting ATP synthase complex CC 19 4 6.25883E-05 0.01220
mitochondrial membrane part CC 117 8 7.21148E-05 0.01360
mitochondrial part CC 404 15 8.83156E-05 0.01639
membrane CC 5379 88 0.000106964 0.01924
vacuolar proton-transporting V-type ATPase, V0 domain CC 9 3 0.000127733 0.02229
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) CC 12 3 0.000325933 0.04885
proton-transporting V-type ATPase, V0 domain CC 12 3 0.000325933 0.04885
ATPase activity, coupled to transmembrane movement of ions, rotational mechanism MF 34 7 1.1446E-07 0.00045
hydrogen ion transmembrane transporter activity MF 84 9 6.11883E-07 0.00060
ATPase activity, coupled to transmembrane movement of substances MF 98 9 2.27123E-06 0.00166
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances MF 101 9 2.92425E-06 0.00172
primary active transmembrane transporter activity MF 104 9 3.73269E-06 0.00178
P-P-bond-hydrolysis-driven transmembrane transporter activity MF 104 9 3.73269E-06 0.00178
cation-transporting ATPase activity MF 56 7 3.96731E-06 0.00178
ATPase coupled ion transmembrane transporter activity MF 56 7 3.96731E-06 0.00178
ATPase activity, coupled to movement of substances MF 112 9 6.88692E-06 0.00260
active ion transmembrane transporter activity MF 96 8 1.72916E-05 0.00546
active transmembrane transporter activity MF 281 13 2.87859E-05 0.00797
proton-transporting ATP synthase activity, rotational mechanism MF 16 4 3.02121E-05 0.00803
transporter activity MF 991 25 0.000249051 0.04101
substrate-specific transmembrane transporter activity MF 709 20 0.000263528 0.04279
ion transmembrane transporter activity MF 660 19 0.000293184 0.04572
substrate-specific transporter activity MF 828 22 0.000297009 0.04572
monovalent inorganic cation transmembrane transporter activity MF 264 11 0.000297217 0.04572
  1. GOs are grouped by ontology (BP, CC or MF) and ranked by FDR-corrected p-value