Table 1 GOs enriched for genes differentially expressed between heterozygous mutant and wild type sibling fish brains
Gene Ontology Term | Ontology | Total Genes | DE Genes | p-value | FDR p-value |
|---|---|---|---|---|---|
ATP biosynthetic process | BP | 29 | 7 | 3.48987E-08 | 0.00041 |
ribonucleoside triphosphate biosynthetic process | BP | 49 | 8 | 9.41317E-08 | 0.00045 |
nucleoside triphosphate biosynthetic process | BP | 54 | 8 | 2.06555E-07 | 0.00060 |
purine nucleoside triphosphate biosynthetic process | BP | 41 | 7 | 4.46237E-07 | 0.00060 |
purine ribonucleoside triphosphate biosynthetic process | BP | 41 | 7 | 4.46237E-07 | 0.00060 |
hydrogen transport | BP | 60 | 8 | 4.783E-07 | 0.00060 |
proton transport | BP | 60 | 8 | 4.783E-07 | 0.00060 |
energy coupled proton transport, down electrochemical gradient | BP | 27 | 6 | 5.89038E-07 | 0.00060 |
ATP synthesis coupled proton transport | BP | 27 | 6 | 5.89038E-07 | 0.00060 |
transport | BP | 2072 | 48 | 2.11748E-06 | 0.00165 |
purine nucleoside monophosphate biosynthetic process | BP | 54 | 7 | 3.09019E-06 | 0.00172 |
purine ribonucleoside monophosphate biosynthetic process | BP | 54 | 7 | 3.09019E-06 | 0.00172 |
hydrogen ion transmembrane transport | BP | 54 | 7 | 3.09019E-06 | 0.00172 |
ribonucleoside triphosphate metabolic process | BP | 133 | 10 | 3.8448E-06 | 0.00178 |
establishment of localization | BP | 2123 | 48 | 4.20295E-06 | 0.00182 |
ATP metabolic process | BP | 109 | 9 | 5.50772E-06 | 0.00230 |
nucleoside triphosphate metabolic process | BP | 140 | 10 | 6.08925E-06 | 0.00245 |
cation transport | BP | 452 | 18 | 6.61154E-06 | 0.00258 |
monovalent inorganic cation transport | BP | 219 | 12 | 1.10729E-05 | 0.00392 |
ribonucleoside monophosphate biosynthetic process | BP | 65 | 7 | 1.08944E-05 | 0.00392 |
nucleoside monophosphate biosynthetic process | BP | 68 | 7 | 1.47269E-05 | 0.00492 |
purine ribonucleoside triphosphate metabolic process | BP | 125 | 9 | 1.68142E-05 | 0.00546 |
purine nucleoside triphosphate metabolic process | BP | 126 | 9 | 1.79263E-05 | 0.00552 |
transmembrane transport | BP | 654 | 21 | 2.93288E-05 | 0.00797 |
purine nucleoside monophosphate metabolic process | BP | 136 | 9 | 3.2951E-05 | 0.00837 |
purine ribonucleoside monophosphate metabolic process | BP | 136 | 9 | 3.2951E-05 | 0.00837 |
energy coupled proton transmembrane transport, against electrochemical gradient | BP | 35 | 5 | 5.20342E-05 | 0.01106 |
ATP hydrolysis coupled proton transport | BP | 35 | 5 | 5.20342E-05 | 0.01106 |
ATP hydrolysis coupled transmembrane transport | BP | 35 | 5 | 5.20342E-05 | 0.01106 |
ATP hydrolysis coupled ion transmembrane transport | BP | 35 | 5 | 5.20342E-05 | 0.01106 |
ATP hydrolysis coupled cation transmembrane transport | BP | 35 | 5 | 5.20342E-05 | 0.01106 |
ion transport | BP | 737 | 22 | 5.61478E-05 | 0.01152 |
localization | BP | 2621 | 52 | 6.0913E-05 | 0.01207 |
ribonucleoside monophosphate metabolic process | BP | 147 | 9 | 6.06496E-05 | 0.01207 |
nucleoside monophosphate metabolic process | BP | 150 | 9 | 7.09445E-05 | 0.01360 |
single-organism localization | BP | 819 | 23 | 9.51294E-05 | 0.01738 |
single-organism transport | BP | 776 | 22 | 0.000119082 | 0.02109 |
ribonucleotide biosynthetic process | BP | 129 | 8 | 0.000143028 | 0.02423 |
ribose phosphate biosynthetic process | BP | 129 | 8 | 0.000143028 | 0.02423 |
vacuolar acidification | BP | 11 | 3 | 0.000246582 | 0.04101 |
ribonucleotide metabolic process | BP | 220 | 10 | 0.000281352 | 0.04506 |
proton-transporting two-sector ATPase complex, proton-transporting domain | CC | 25 | 6 | 3.59375E-07 | 0.00060 |
proton-transporting two-sector ATPase complex | CC | 45 | 7 | 8.65692E-07 | 0.00078 |
mitochondrial membrane | CC | 285 | 15 | 1.42199E-06 | 0.00119 |
mitochondrial envelope | CC | 303 | 15 | 3.0322E-06 | 0.00172 |
membrane part | CC | 4868 | 85 | 1.1722E-05 | 0.00403 |
organelle membrane | CC | 789 | 24 | 1.84982E-05 | 0.00555 |
mitochondrial inner membrane | CC | 195 | 11 | 1.97958E-05 | 0.00579 |
integral component of membrane | CC | 4419 | 78 | 2.52479E-05 | 0.00720 |
intrinsic component of membrane | CC | 4453 | 78 | 3.37749E-05 | 0.00840 |
organelle envelope | CC | 420 | 16 | 3.76291E-05 | 0.00917 |
envelope | CC | 422 | 16 | 3.98337E-05 | 0.00950 |
organelle inner membrane | CC | 215 | 11 | 4.86028E-05 | 0.01106 |
Cul2-RING ubiquitin ligase complex | CC | 7 | 3 | 5.4156E-05 | 0.01131 |
proton-transporting ATP synthase complex | CC | 19 | 4 | 6.25883E-05 | 0.01220 |
mitochondrial membrane part | CC | 117 | 8 | 7.21148E-05 | 0.01360 |
mitochondrial part | CC | 404 | 15 | 8.83156E-05 | 0.01639 |
membrane | CC | 5379 | 88 | 0.000106964 | 0.01924 |
vacuolar proton-transporting V-type ATPase, V0 domain | CC | 9 | 3 | 0.000127733 | 0.02229 |
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | CC | 12 | 3 | 0.000325933 | 0.04885 |
proton-transporting V-type ATPase, V0 domain | CC | 12 | 3 | 0.000325933 | 0.04885 |
ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | MF | 34 | 7 | 1.1446E-07 | 0.00045 |
hydrogen ion transmembrane transporter activity | MF | 84 | 9 | 6.11883E-07 | 0.00060 |
ATPase activity, coupled to transmembrane movement of substances | MF | 98 | 9 | 2.27123E-06 | 0.00166 |
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | MF | 101 | 9 | 2.92425E-06 | 0.00172 |
primary active transmembrane transporter activity | MF | 104 | 9 | 3.73269E-06 | 0.00178 |
P-P-bond-hydrolysis-driven transmembrane transporter activity | MF | 104 | 9 | 3.73269E-06 | 0.00178 |
cation-transporting ATPase activity | MF | 56 | 7 | 3.96731E-06 | 0.00178 |
ATPase coupled ion transmembrane transporter activity | MF | 56 | 7 | 3.96731E-06 | 0.00178 |
ATPase activity, coupled to movement of substances | MF | 112 | 9 | 6.88692E-06 | 0.00260 |
active ion transmembrane transporter activity | MF | 96 | 8 | 1.72916E-05 | 0.00546 |
active transmembrane transporter activity | MF | 281 | 13 | 2.87859E-05 | 0.00797 |
proton-transporting ATP synthase activity, rotational mechanism | MF | 16 | 4 | 3.02121E-05 | 0.00803 |
transporter activity | MF | 991 | 25 | 0.000249051 | 0.04101 |
substrate-specific transmembrane transporter activity | MF | 709 | 20 | 0.000263528 | 0.04279 |
ion transmembrane transporter activity | MF | 660 | 19 | 0.000293184 | 0.04572 |
substrate-specific transporter activity | MF | 828 | 22 | 0.000297009 | 0.04572 |
monovalent inorganic cation transmembrane transporter activity | MF | 264 | 11 | 0.000297217 | 0.04572 |