Fig. 5
From: A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
Change in basic synapse transmission and LTP in the hippocampus of PP2A CKO mice. a Input-output curves for the CA1 dendritic fEPSP slope evoked by Schaffer commissural fibre stimulation in hippocampal slices from Cont and CKO mice (N = 3/group, n = 9/group). b The basis of synaptic transmission capacity was significantly lower in CKO mice than in Cont mice (N = 5/group, n = 18/group). c, d LTP could be evoked by 2 × TBS in both Cont and CKO mice (C, N = 3/group, n = 6/group). However, LTP induced by 50-Hz HFS was impaired in CKO mice (D, N = 3/group, n = 6/group). Vertical scale bar represents 0.2 mV; horizontal scale bar represents 50 ms. ** p < 0.01, *** p < 0.001