Fig. 3

Normal motor function in double mutant mice. a Polr3a^G672E/G672E and Polr3b^+/R103H mice were crossed to generate double mutant mice that are homozygous for the Polr3a G672E mutation and heterozygous for the Polr3b R103H mutation. b Results from the 6 mm beam test at 6 months of age in males and females. Latencies to cross (top) and number of foot slips (bottom) are shown. For each mouse, three trials were performed and summed. c Results from the rotarod at 6 months of age in males and females. For each mouse, three trials were performed and summed. d Results from the open field test at 6 months of age in an independent cohort of males only. The open field test was run for 90 min per mouse during which total distance traveled (left), total time spent moving (middle) and number of movement bouts (right) were recorded for each 10 min interval