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Fig. 3 | Molecular Brain

Fig. 3

From: LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration

Fig. 3

Reduced pyramidal neurons in the upper cortical layer of LIMK KO mice. a and b Sample coronal brain sections stained for the late-born neuronal marker Brn2 (red) and BrdU (green) injected at E14.5, showing co-location of Brn2+ and BrdU+ neurons (yellow) in the upper layer of P0 cortex. c Summary graph showing reduced Brn2+/BrdU+ neurons in LIMK1 KO, LIMK2 KO and LIMK1/2 DKO mice. WT n = 6, LIMK1 KO n = 5, LIMK2 KO n = 5, LIMK1/2 DKO n = 3. Data are presented as mean ± SEM. *p < 0.05, one-way ANOVA, Dunnett’s test. Scale bars, 50 μm

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