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Fig. 4 | Molecular Brain

Fig. 4

From: LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration

Fig. 4

Impaired neuronal migration in in LIMK KO mice. a Pregnant mice were labeled with BrdU at E14.5 and postnatal day 0 (P0) pups were stained for BrdU showing reduced BrdU+ cells in LIMK1 KO, LIMK2 KO and LIMK1/2 DKO mice. b Summary graph showing reduced total BrdU+ cells in LIMK1 KO, LIMK2 KO and LIMK1/2 DKO mice. c Distribution of BrdU+ cells across the cortex from (a), 1–10 represent the spatial order from VZ/SVZ to CP. WT control, n = 6; LIMK1 KO, n = 5; LIMK2 KO, n = 5; LIMK1/2 DKO, n = 3. Data are presented as mean ± SEM. Statistical significance was determined by one-way ANOVA, Dunnett’s test. *p < 0.05, **p < 0.01. Scale bars, 50 μm

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