Fig. 5
From: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels
Both AnkB and Cav2.1 show similar increase in expression during early cortical development. (ai) Representative Western blots of AnkB and Cav2.1 in mice cortex, hippocampus, and cerebellum from P7 to P60. (aii) Quantification of AnkB and Cav2.1 normalized to stain-free. One-way ANOVA followed by Dunnett’s multiple comparison, N = 3, F (3, 8) = 12.52, p = 0.0022 (cortex, AnkB); F (3, 8) = 4.945, p = 0.0314 (cortex, Cav2.1); F (3, 8) = 28.89, p = 0.0001 (cerebellum, AnkB); F (3, 8) = 0.9790, p = 0.4494 (cerebellum, Cav2.1); F (3, 8) = 15.70, p = 0.0010 (hippocampus, AnkB); F (3, 8) = 4.507, p = 0.0393 (hippocampus, Cav2.1). (bi-ii) Representative Western blots of inputs and control IgG or AnkB immunoprecipitation from P14 mouse cortex. N = 3. This data is included in the MSc thesis of CSWC, University of Victoria, 2019 found at https://dspace.library.uvic.ca//handle/1828/11053