Skip to main content
Fig. 7 | Molecular Brain

Fig. 7

From: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels

Fig. 7

Working model of AnkB’s regulation of Cav2.1. In the absence of AnkB, Cav2.1 is expressed at a low level in the cell. In the presence of wildtype AnkB, Cav2.1 may be protected from degradation and therefore has higher intracellular levels while maintaining low surface levels. With the AnkB p.S646F variant, Cav2.1 is expressed at an even higher level intracellularly, but maintains the same surface expression levels. The AnkB p.Q879R variant increases surface Cav2.1, while AnkB p.E1458G decreases surface Cav2.1 levels. AnkB wildtype, p.S646F, and p.Q879R all had a surface-associated pool in the presence of Cav accessory subunits. There was no significant surface-associated pool with AnkB p.E1458G. This figure is included in the MSc thesis of CSWC, University of Victoria, 2019 found at https://dspace.library.uvic.ca//handle/1828/11053

Back to article page