Fig. 7
From: Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex
Nsun5 deficiency reduces the Cdc42 expression. a Representative images of double immunostaining for Cdc42 (green) and Nsun5 (red) in E14.5 WT mice (WT). Scale bars, 50 μm. b Representative images of Cdc42 immunoreactivity (open arrows) in E14.5 WT mice (WT) and Nsun5-KO mice (KO). Scale bars, 50 μm. c Levels of Cdc42, RhoA, PKCζ and Akt mRNA. d Levels of Cdc42, RhoA, PKCζ and Akt protein in cerebral cortex of WT mice and Nsun5-KO mice. **P < 0.01 vs. WT mice. e-g Levels of PKC (p-PKC), Akt (p-Akt), GSK3β at Y216 (p-GSK3β-Y216) and GSK3β at S9 (p-GSK3β-S9) phosphorylation