Fig. 3

Post-LTP is occluded within aIC in rats with CP. a: Light microscopy photograph showing relative location of aIC within the probe. b: Schematic diagram showing the recording array arrangement. c: The input-output curve of the number of activated channels in slices of sham and CP rats, one-way repeated ANOVA. d, e: A sample of an overview of multisite synaptic responses recorded at baseline (black) and 2 h after TBS (red) in sham and CP groups, respectively. The flash denotes the stimulated channel. Red and black filled circles mark all activated channels undergoing and not undergoing LTP, respectively, while the black rectangle represents a typical channel not exhibiting any response in the baseline. These example traces are shown in an enlarged scale below. Vertical lines demarcate different layers. f, g: Time course of averaged fEPSP slope and amplitude of all active channels in sham and TNBS groups. The arrow indicates the time of TBS application. Dashed line indicates the baseline of 100% slope or amplitude. h: The average slope and amplitude of fEPSPs of all active channels within the last 20 min of 140 min recording in sham and TNBS groups, unpaired t-test. i, j: The polygonal diagram of activated (blue) and LTP-occurring (red) channels within aIC after TBS in sham (i) and TNBS (j) groups. The red dots indicate the stimulation sites. n = 6 slices from 6 rats in each group. * P < 0.05, ** P < 0.01, *** P < 0.001, TNBS vs sham