Skip to main content
Fig. 4 | Molecular Brain

Fig. 4

From: Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats

Fig. 4

Enhanced pyramidal neuron excitability within aIC after TNBS treatment. a: Schematic diagram indicating the placement of stimulating and recording electrodes in the aIC. b: The different firing patterns of pyramidal neuron (left, repetitive action potentials with frequency adaptation) and interneuron (right, fast-spike firing) within aIC after positive current injected into the cell under current-clamp mode. c: Sample traces of the spikes recorded in pyramidal neurons within the superficial layer of aIC of sham (left) and CP (right) rats in response to depolarizing current injections, step = 100 pA, duration = 400 ms. d: The spike number input-output curve from CP rats was steeper than that from sham rats, one-way repeated ANOVA. e: Sample traces showing CP rats exhibited decreased rheobase current (42 pA in CP rats vs 194 pA in sham rats) and hyperpolarized RMP (− 63.30 mV in CP rats vs − 71.22 mV in sham rats) in insular pyramidal neurons, step = 2 pA, duration = 400 ms. f: The rheobase current was decreased in CP rats (74.33 ± 8.97 pA) compared to sham rats (120.7 ± 20.85 pA), unpaired t-test. g: The RMP was increased in CP rats (− 70.3 ± 1.57 mV) compared to sham rats (− 65.67 ± 1.48 mV), unpaired t-test. n = 9 in sham group and 12 in TNBS group, * P < 0.05, TNBS vs sham

Back to article page