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Fig. 9 | Molecular Brain

Fig. 9

From: Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats

Fig. 9

Non-selectively chemogenetic inactivation of bilateral insular neurons alleviates abdomen mechanical hyperalgesia and anxiety-like behavior in CP rats. a: The schematic diagram of the behavioral experiment (up) and rAAV2/9-hSyn-hM4Di-mCitrine construct (down). b: A representative coronal section showing virus injection sites within bilateral aIC. Bar = 1 mm. c: Inhibiting bilateral insular neurons via i.p. CNO injection significantly increased the AWT in CP rats on POD 14. d, e: Inhibiting bilateral insular neurons led to a trend toward increased total traveling distance (d) and a significant increase in central traveling distance (e) in CP rats. n = 7 in mCitrine group and 6 in Gi group, unpaired t-test. * P < 0.05, ** P < 0.01, Gi vs mCitrine

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