Skip to main content
Fig. 4 | Molecular Brain

Fig. 4

From: Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli

Fig. 4

Replacing e37a-Cacna1b mRNA by e37b-Cacna1b results in enhanced probability of transmitter release in mPP-DG synapses. a Schematic describing approximate placement of recording (rec) and stimulation (stim) electrodes in the superior blade of DG and s.r. in CA1. b I/O relationships of fEPSPs from mPP-DG synapses recorded in WT and e37b-only mice. Slopes of fEPSPs were plotted as a function of the stimulus intensity. c I/O of fEPSPs from SC-CA1 synapses recorded in WT and e37b-only mice. Slopes of fEPSPs were plotted as a function of the stimulus intensity. d Representative traces of mPP-DG fEPSPs using a PPR protocol in WT and e37b-only slices (left panel). PPR of fEPSPs recorded at varying pulse intervals in slices of WT and e37b-only (right panel). e Representative traces of SC-CA1 fEPSPs using a PPR protocol in WT and e37b-only slices (left panel). PPR of fEPSPs recorded at varying pulse intervals in slices of WT and e37b-only mice (right panel). b-e. Data are shown as mean ± SE

Back to article page