Fig. 2
From: Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice
Chemical shift imaging of hyperpolarized 13C MRS. a Color maps overlaid on the 1H images represent [1-13C] pyruvate and [1-13C] lactate peak intensities, and [1-13C] lactate/total 13C intensity ratios. The images were acquired for 35 s from 18 s after intravenous injection of 79 mM of hyperpolarized 13C-pyruvate in the coronal plane with a 3.5-mm slice thickness and 1 × 1 mm2 in-plain resolution. White boxes indicate voxels containing hippocampus. b [1-13C] lactate/total 13C intensity ratios calculated each voxel of the region containing the whole brain, striatum, hippocampus, and midbrain. Values are expressed as mean ± SEMs (n = 4–5 for both groups). * p < 0.05