Fig. 2
From: Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice
Voluntary wheel running (VWR) increases the number and the thickness of myelinated axons in the motor cortex. a Representative electron micrographs of axon and myelin in control (Ctrl) and VWR mice. b Quantification of myelinated axons per field of view (FOV = 506 μm2) in Ctrl and VWR mice. c, d G-ratio analysis for the thickness of myelin in Ctrl and VWR mice. e Diameter of axons in Ctrl and VWR mice. For electron microscopy, enough independent fields were quantified to achieve at least 150 axons per group. Data are presented as mean ± SEM. n = 150 from3 mice per group. *p < 0.05 vs Ctrl; **p < 0.01 vs Ctrl; ns, p > 0.05, unpaired Student’s t-test and Pearson’s rank correlation test