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Fig. 3 | Molecular Brain

Fig. 3

From: Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice

Fig. 3

Voluntary wheel running (VWR) accelerates OPC proliferation and OL maturation in the motor cortex. a Confocal images of PDGFRα- and Olig2-possive cells in the motor cortex of control (Ctrl) and VWR mice. Scale bar = 50 μm. b VWR mice have significantly more oligodendroglial lineage cells (Olig2+) than Ctrl mice. c VWR mice have statistically equal number of OPCs (PDGFRα+Olig2+) as control mice. d Confocal images of CC1- and Olig2-positive cells in the motor cortex of Ctrl and VWR mice. Scale bar = 40 μm. e VWR mice have significantly more mature OLs (CC1+Olig2+) than Ctrl mice. f Confocal images of BrdU- and NG2-positive cells in the motor cortex of Ctrl and VWR mice. Scale bar = 60 μm. g VWR mice have significantly more newly generated OPCs (NG2+ BrdU+) than Ctrl mice. Data are presented as minimum to maximum. n = 8 per group. *p < 0.05 vs Ctrl; ns, p > 0.05;**p < 0.01 vs Ctrl; unpaired Student’s t-test

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