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Fig. 6 | Molecular Brain

Fig. 6

From: Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice

Fig. 6

Voluntary wheel running (VWR) promotes myelination via inhibiting the expression of Wnt3a and Wnt9a. a The mRNA levels of Wnts in the motor cortex of control (Ctrl) and VWR mice. Data are presented as mean ± SEM. n = 6 per group; ***p < 0.001 vs Ctrl, unpaired Student’s t-test. b Expression of Wnt3a and Wnt9a in HEK293 cells. CM, Cell membrane. c, d Wnt3a- and Wnt9a-treated OPCs immunostained for NG2 (OPCs). As shown, the number of OPCs decreased upon treatment with Wnt3a or Wnt9a. Scale bar = 20 μm. Data are presented as minimum to maximum. n = 7 independent coverslips per condition. *p < 0.05 vs Ctrl; **p < 0.01 vs Ctrl; unpaired Student’s t-test. e, f Wnt3a- and Wnt9a-treated OPCs immunostained for MBP (OLs). The average branch length of OLs decreased upon treatment with Wnt3a or Wnt9a. Scale bars = 20 μm. Data are presented as minimum to maximum. n = 7 independent coverslips per condition. **p < 0.01 vs Ctrl;*p < 0.05 vs Ctrl; unpaired Student’s t-test

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