Fig. 2
From: Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy
Biophysical analysis of variants R1282W and A1765V in cis. a Average current densities (pA/pF) as a function of voltage for WT and R1282W-A1765V channels, showing an increase in current density for R1282W-A1765V. Numbers in parentheses reflect numbesr of cells. b Mean half-voltage of activation values for R1282W-A1765V compared to WT channels. c Steady-state of inactivation curves for WT and R1282W-A1765V channels. The steady state activation curves extracted from the current-voltage relations in panel (a) are superimposed to highlight the window currents. d Mean half-voltage of inactivation values for R1282W-A1765V compared to WT channels. ****p < 0.0001, Student’s t-test