Table 1 Summary of electrophysiological parameters of wild-type (WT), R1282W and A1765V channels expressed in tsA-201 cells
From: Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy
Peak current density (pA/pF) | Gmax (nS) | V1/2 act (mV) | V1/2 inac (mV) | τrecov (ms) | |
|---|---|---|---|---|---|
WT | −34.39 ± 3.7 (17) | 0.6 ± 0.06 (17) | −40.94 ± 0.9 (17) | −62.1 ± 0.9 (15) | 239.4 ± 28.5 (14) |
R1282W | −69.8 ± 10.8 (26)* | 1.1 ± 0.15 (26)* | −43.5 ± 1.0 (26) | −62.2 ± 0.8 (16) | 287.1 ± 26.9 (9) |
A1765V | −35.7 ± 5.6 (12) | 0.6 ± 0.09 (12) | − 41.9 ± 0.9 (12) | −62.3 ± 0.6 (17) | 259.3 ± 25.4 (11) |