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Table 1 Summary of electrophysiological parameters of wild-type (WT), R1282W and A1765V channels expressed in tsA-201 cells

From: Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy

  Peak current density (pA/pF) Gmax (nS) V1/2 act (mV) V1/2 inac (mV) τrecov (ms)
WT −34.39 ± 3.7 (17) 0.6 ± 0.06 (17) −40.94 ± 0.9 (17) −62.1 ± 0.9 (15) 239.4 ± 28.5 (14)
R1282W −69.8 ± 10.8 (26)* 1.1 ± 0.15 (26)* −43.5 ± 1.0 (26) −62.2 ± 0.8 (16) 287.1 ± 26.9 (9)
A1765V −35.7 ± 5.6 (12) 0.6 ± 0.09 (12) − 41.9 ± 0.9 (12) −62.3 ± 0.6 (17) 259.3 ± 25.4 (11)
  1. Data are represented as mean ± SEM. Numbers in parentheses represent number of cells analyzed. *p < 0.05, One Way ANOVA followed by Tukey’s multiple comparison test