Fig. 3

GAREM2 KO mice exhibited reduced anxiety-like behavior in EPM test (a and b). a Graph showing that the time (%) spent in open arms in GAREM2 KO mice was higher than WT mice. N = 16 for each genotype. Error bars indicate SEM. b Heat maps show the time spent in open and closed arm in WT (left panel) and GAREM2 KO mice (right panel). GAREM2 KO mice exhibited a tendency to be close to each other in the direct social interaction test. c-e Graphs showing the closed time, direct interaction time, and social interaction time (sec), respectively in WT and GAREM2 KO mice. In the direct social interaction test, the combined total of closed time and direct interaction time was denoted as “social interaction time”. N = 8 pair for each genotype and error bars indicate SEM